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The expression of NOB1 was also found to be higher in multidrug-resistant gastric cancer cells than that of sensitive cells. This novel MAb will be valuable for investigating the role of NOB1 in carcinogenesis and multidrug resistance of gastric cancer.
CONCLUSION: Our results suggest that enhanced expression of NOB1 related with poor early response to cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer
NOB1 plays an oncogenic role in laryngeal cancer cells through the regulation of JNK (show MAPK8 Proteins) signaling pathway.
miR (show MLXIP Proteins)-139-3p may act as a tumor suppressor that can inhibitcervical cancer cell proliferation, migration and invasion and induce cell apoptosis through down-regulation of NOB1 expression.
we suggest that targeting miR (show MLXIP Proteins)-192 and NOB1 is a novel strategy which will assist in the development of new therapeutics that will be used in the future to prevent and treat prostate cancer.
The results suggested that NOB1 is important in OSCC development and serves as a candidate indicator of aggressiveness and a therapeutic target of oral squamous cell carcinoma.
These results suggest that NOB1 may act as an important regulator in non-small cell lung cancer growth and could be a therapeutic target of nonsmall cell lung cancer.
Downregulation of miR (show MLXIP Proteins)-326 inhibited tumor proliferation and tumor metastasis by directly targeting NOB1 in colorectal carcinoma. Upregulation of miR (show MLXIP Proteins)-326 in CRC (show CALR Proteins) cells was revealed to be associated with a feedback loop involving downregulation of the NOB1.
Enhanced expression of NOB1 is related to poor overall survival and progression-free survival in patients with resected non-small cell lung cancer.
Enhanced expression of NOB1 gene plays an important role in the occurrence and development of NSCLC.
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
, nin one binding protein
, RNA-binding protein nob1
, RNA-binding protein NOB1
, PSMD8 binding protein 1
, adenocarcinoma antigen recognized by T lymphocytes 4
, phosphorylation regulatory protein HP-10
, protein ART-4
, likely ortholog of mouse nin one binding protein