Browse our anti-TXNIP (TXNIP) Antibodies

Human Thioredoxin Interacting Protein (TXNIP) interaction partners

1. Using oxygen-glucose deprivation and reoxygenation (OGD (show FGFR1 Antibodies)/R) to create a cell model of hepatic I/R injury, we found that the mRNA and protein expression levels of TXNIP were upregulated in HL7702cells exposed to OGD (show FGFR1 Antibodies)/R.

2. Thioredoxin-interacting protein (TXNIP) is highly induced in retinal vascular endothelial cells under diabetic conditions. Data (including data from studies using knockout mice) suggest that TXNIP in retinal vascular endothelial cells plays role in diabetic retinal angiogenesis via VEGF (show VEGFA Antibodies)/VEGFR2 (show KDR Antibodies) and Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling. (VEGFR2 (show KDR Antibodies) = vascular endothelial growth factor receptor-2 (show KDR Antibodies))

3. miR (show MLXIP Antibodies)-20a could negatively regulate TLR4 (show TLR4 Antibodies) and NLRP3 (show NLRP3 Antibodies) signaling to protect human aortic endothelial cells from inflammatory injuries.

4. Results found the mRNA level of TRX-1 (show MLL Antibodies) was significantly decreased (p<0.005), while the mRNA levels of TBP-2 (show Tbpl2 Antibodies), COX-2 (show COX2 Antibodies), and TNF-alpha (show TNF Antibodies) were significantly increased in the placentas in preeclampsia when compared to the normal group.

5. Consistent with its enhanced expression in Laron syndrome, we provide evidence that TXNIP gene expression is negatively regulated by IGF1 (show IGF1 Antibodies).

6. TXNIP contributes to the dysregulation of tubular autophagy and mitophagy in diabetic nephropathy through activation of the mTOR (show FRAP1 Antibodies) signaling pathway.

7. This study thus characterizes ERK (show EPHB2 Antibodies)-mediated suppression of TXNIP as a presently unreported mechanism by which ap junctions regulate cell behaviors.

8. Results indicate an internal ribosome entry sites (IRESes) within the thioredoxin-interacting protein (TXNIP) protein; 5' untranslated region (5'UTR (show UTS2R Antibodies)), and regulatory IRES trans-acting factors.

9. The data of this study suggested that TXNIP blocked autophagic flux and induced alpha-synuclein accumulation through inhibition of ATP13A2 (show ATP13A2 Antibodies).

10. Compared with normal tissues, TXNIP expression was significantly decreased in human breast cancer tissues and canine mammary tumors, along with tumor progression.

Mouse (Murine) Thioredoxin Interacting Protein (TXNIP) interaction partners

1. Thioredoxin-interacting protein (Txnip) is highly induced in retinal vascular endothelial cells under diabetic conditions. Data (including data from studies using knockout mice) suggest that Txnip in retinal vascular endothelial cells plays role in diabetic retinal angiogenesis via Vegf (show VEGFA Antibodies)/Vegfr2 (show KDR Antibodies) and Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling. (Vegfr2 (show KDR Antibodies) = vascular endothelial growth factor receptor-2 (show KDR Antibodies))

2. These results suggest that mitochondrial ROS (show ROS1 Antibodies)-TXNIP/NLRP3 (show NLRP3 Antibodies)/IL-1beta (show IL1B Antibodies) axis activation is responsible for tubular oxidative injury, which can be ameliorated by MitoQ via the inhibition of mtROS overproduction

3. crucial role in haematopoietic stem cell aging by inhibiting p38 (show CRK Antibodies) activity via direct interaction

4. Data show that p38MAPK (show MAPK14 Antibodies) phosphorylation significantly increased in lentivirus vector thioredoxin interacting protein (LV-GFP-TXNIP) cells.

5. Endogenous hydrogen sulfide (show SQRDL Antibodies)-mediated MAPK (show MAPK1 Antibodies) inhibition preserves endothelial function through TXNIP signaling.

6. NLR (show CXCR5 Antibodies) family, pyrin domain containing 3 protein (NLRP3 (show NLRP3 Antibodies))-/- mice exhibited less severe non-alcoholic steatohepatitis (NASH (show SAMSN1 Antibodies)) than WT mice, whereas thioredoxin-interacting protein (TXNIP) deficiency enhanced NLRP3 (show NLRP3 Antibodies) inflammasome.

7. TXNIP is a direct substrate of protein kinase B (AKT (show AKT1 Antibodies)) and is responsible for mediating AKT (show AKT1 Antibodies)-dependent acute glucose influx after growth factor stimulation.

8. Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS (show ROS1 Antibodies)-TXNIP-NLRP3 (show NLRP3 Antibodies) axis in vitro. This provides new insight into the relationship between hypoxia and inflammation in T2D.

9. Here the authors demonstrate that thioredoxin-interacting protein (Txnip), which regulates glucose homeostasis in mammals, binds to fructose transporters and promotes fructose absorption by the small intestine.

10. thioredoxin-interacting protein deficiency alleviates diabetic renal lipid accumulation through regulation of Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway

Pig (Porcine) Thioredoxin Interacting Protein (TXNIP) interaction partners

1. The molecular characterization of porcine TXNIP gene, is described.

2. single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain

Cow (Bovine) Thioredoxin Interacting Protein (TXNIP) interaction partners

1. Foam cell-released 4-hydroxnonenal activates PPARdelta (show PPARD Antibodies) in Vascular endothelial cells, leading to increased TXNIP expression and consequently to senescence.