Browse our anti-TXNIP (TXNIP) Antibodies

Human Thioredoxin Interacting Protein (TXNIP) interaction partners

1. Consistent with its enhanced expression in Laron syndrome, we provide evidence that TXNIP gene expression is negatively regulated by IGF1 (show IGF1 Antibodies).

2. TXNIP contributes to the dysregulation of tubular autophagy and mitophagy in diabetic nephropathy through activation of the mTOR (show FRAP1 Antibodies) signaling pathway.

3. This study thus characterizes ERK (show EPHB2 Antibodies)-mediated suppression of TXNIP as a presently unreported mechanism by which ap junctions regulate cell behaviors.

4. Results indicate an internal ribosome entry sites (IRESes) within the thioredoxin-interacting protein (TXNIP) protein; 5' untranslated region (5'UTR (show UTS2R Antibodies)), and regulatory IRES trans-acting factors.

5. The data of this study suggested that TXNIP blocked autophagic flux and induced alpha-synuclein accumulation through inhibition of ATP13A2 (show ATP13A2 Antibodies).

6. Compared with normal tissues, TXNIP expression was significantly decreased in human breast cancer tissues and canine mammary tumors, along with tumor progression.

7. This finding suggested statistically significant role of interaction of TXNIP and AF1q (show MLLT11 Antibodies) polymorphisms (TXNIP-rs2236566, TXNIP-rs7211, and AF1q (show MLLT11 Antibodies)-rs2769605) in schizophrenia susceptibility.

8. summarize the current state of our understanding of TXNIP biology, highlight its role in metabolic regulation and raise critical questions that could help future research to exploit TXNIP as a therapeutic target

9. intracellular TXNIP protein is a critical regulator of activation of the fructose-induced NLRP3 (show NLRP3 Antibodies) inflammasome

10. This study provides insight into the molecular mechanisms of TXNIP overexpression in liver cancer cell survival and apoptosis and indicated that TXNIP may be a novel promising agent for liver cancer treatment.

Pig (Porcine) Thioredoxin Interacting Protein (TXNIP) interaction partners

1. The molecular characterization of porcine TXNIP gene, is described.

2. single-marker and haplotype analyses revealed significant effects of TXNIP on hot carcass weight, test daily gain, and lifetime daily gain

Cow (Bovine) Thioredoxin Interacting Protein (TXNIP) interaction partners

1. Foam cell-released 4-hydroxnonenal activates PPARdelta (show PPARD Antibodies) in Vascular endothelial cells, leading to increased TXNIP expression and consequently to senescence.

Mouse (Murine) Thioredoxin Interacting Protein (TXNIP) interaction partners

1. Data show that p38MAPK (show MAPK14 Antibodies) phosphorylation significantly increased in lentivirus vector thioredoxin interacting protein (LV-GFP-TXNIP) cells.

2. Endogenous hydrogen sulfide (show SQRDL Antibodies)-mediated MAPK (show MAPK1 Antibodies) inhibition preserves endothelial function through TXNIP signaling.

3. NLR (show CXCR5 Antibodies) family, pyrin domain containing 3 protein (NLRP3 (show NLRP3 Antibodies))-/- mice exhibited less severe non-alcoholic steatohepatitis (NASH (show SAMSN1 Antibodies)) than WT mice, whereas thioredoxin-interacting protein (TXNIP) deficiency enhanced NLRP3 (show NLRP3 Antibodies) inflammasome.

4. TXNIP is a direct substrate of protein kinase B (AKT (show AKT1 Antibodies)) and is responsible for mediating AKT (show AKT1 Antibodies)-dependent acute glucose influx after growth factor stimulation.

5. Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS (show ROS1 Antibodies)-TXNIP-NLRP3 (show NLRP3 Antibodies) axis in vitro. This provides new insight into the relationship between hypoxia and inflammation in T2D.

6. Here the authors demonstrate that thioredoxin-interacting protein (Txnip), which regulates glucose homeostasis in mammals, binds to fructose transporters and promotes fructose absorption by the small intestine.

7. thioredoxin-interacting protein deficiency alleviates diabetic renal lipid accumulation through regulation of Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway

8. All-trans retinoic acid plays a key role in inhibition of hepatic stellate cell activation via suppressing TXNIP expression, which reduces oxidative stress levels.

9. TXNIP-NFYA (show NFYA Antibodies)-SREBP2 (show SREBF2 Antibodies)/miR (show MLXIP Antibodies)-33a-AMPKalpha (show GRK4 Antibodies)/CROT (show CROT Antibodies)/CPT1 (show CPT1A Antibodies)/HADHB (show HADHB Antibodies) pathway is conserved in mouse, rat, and human cardiomyocytes and regulates myocardial beta-oxidation.

10. results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 (show NLRP3 Antibodies) inflammasome pathway.