TXNIP antibody (C-Term)

Catalog No. ABIN2784817

There is 1 publication for this product available. The Rabbit Polyclonal anti-TXNIP antibody is suitable to detect TXNIP in samples from Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig and Sheep. It has been validated for WB.

Quick Overview for TXNIP antibody (C-Term) (ABIN2784817)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TXNIP Antibody

Binding Specificity: C-Term

Purpose: TXNIP Antibody - C-terminal region

Sequence: DTPEAPPCYM DVIPEDHRLE SPTTPLLDDM DGSQDSPIFM YAPEFKFMPP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%

Characteristics: This is a rabbit polyclonal antibody against TXNIP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TXNIP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52193-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-TXNIP antibody (ABIN2784817)

Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: "Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6912-7, (2008) (PubMed).

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: TXNIP

Background:

Background Information: TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells.

Gene Name: Thioredoxin interacting protein

Alternative Symbols: THIF, VDUP1, ARRDC6, HHCPA78, EST01027

Protein Name: Thioredoxin-interacting protein

Molecular Weight: 44kDa

Gene ID: 10628

NCBI Accession: NP_006463

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome