CBR1 Protein (AA 2-277, full length) (GST tag)

Catalog No. ABIN1046764

This Recombinant CBR1 protein is produced in Escherichia coli (E. coli).

Quick Overview for CBR1 Protein (AA 2-277, full length) (GST tag) (ABIN1046764)

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS), ELISA

Purity: 90 %

Product Details

Protein Characteristics: AA 2-277, full length

Purification tag / Conjugate: This CBR1 protein is labelled with GST tag.

Sequence: SSGIHVALVT GGNKGIGLAI VRDLCRLFSG DVVLTARDVT RGQAAVQQLQ AEGLSPRFHQ LDIDDLQSIR ALRDFLRKEY GGLDVLVNNA GIAFKVADPT PFHIQAEVTM KTNFFGTRDV CTELLPLIKP QGRVVNVSSI MSVRALKSCS PELQQKFRSE TITEEELVGL MNKFVEDTKK GVHQKEGWPS SAYGVTKIGV TVLSRIHARK LSEQRKGDKI LLNACCPGWV RTDMAGPKAT KSPEEGAETP VYLALLPPDA EGPHGQFVSE KRVEQW

Characteristics: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Application Details

Comment:

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS buffer, 20mM GSH

Storage: -20 °C

Target Details

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Alternative Name: Carbonyl reductase [NADPH] 1

Background: Synonyms: 15-hydroxyprostaglandin dehydrogenase [NADP+] NADPH-dependent carbonyl reductase 1 Prostaglandin 9-ketoreductase Prostaglandin-E(2) 9-reductase

Molecular Weight: 57.6 kD

UniProt: P16152