PSMD10 Protein (AA 1-226)
Quick Overview for PSMD10 Protein (AA 1-226) (ABIN1096721)
Target
See all PSMD10 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 1-226
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Purpose
- Recombinant Human Gankyrin/PSDM10
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Sequence
- MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
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Characteristics
- Recombinant Human Gankyrin is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Gly226) of Human PSMD10.
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
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Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-226) protein (His tag)
custom-made PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-231) protein (His tag)custom-made PSMD10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (AA 1-226) protein (GST tag)PSMD10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 1) proteinPSMD10 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PSMD10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Reconstitution
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. -
Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 10 % Glycerol, pH 7.4.
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Handling Advice
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
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Storage
- -80 °C
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Storage Comment
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. -
Expiry Date
- 6 months
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- PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))
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Alternative Name
- gankyrin
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Background
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Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
Alternative Names: 26S Proteasome Non-ATPase Regulatory Subunit 10, 26S Proteasome Regulatory Subunit p28, Gankyrin, p28(GANK), PSMD10 -
Molecular Weight
- 24.43 kDa
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UniProt
- O75832
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Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway
Target
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