Kallikrein 4 Protein (AA 27-254) (His tag)

Catalog No. ABIN1097012

This Recombinant Kallikrein 4 protein is expressed in Human Cells.

Quick Overview for Kallikrein 4 Protein (AA 27-254) (His tag) (ABIN1097012)

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 27-254

Purification tag / Conjugate: This Kallikrein 4 protein is labelled with His tag.

Purpose: Recombinant Human Kallikrein 4/KLK4 (C-6His)

Sequence: SCSQIINGED CSPHSQPWQA ALVMENELFC SGVLVHPQWV LSAAHCFQNS YTIGLGLHSL EADQEPGSQM VEASLSVRHP EYNRPLLAND LMLIKLDESV SESDTIRSIS IASQCPTAGN SCLVSGWGLL ANGRMPTVLQ CVNVSVVSEE VCSKLYDPLY HPSMFCAGGG QDQKDSCNGD SGGPLICNGY LQGLVSFGKA PCGQVGVPGV YTNLCKFTEW IEKTVQASVD HHHHHH

Characteristics:

Recombinant Human Kallikrein 4/KLK4 (C-6His)

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Alternative Name: kallikrein-4

Background: Recombinant Human Kallikrein 4 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (I31-S254) of Human KLK4 fused with a polyhistidine tag at the C-terminus.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen members of the Kallikrein subfamily located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.

Molecular Weight: 25.44 kDa

UniProt: Q9Y5K2

Pathways: Complement System