HAX1 Protein (AA 1-279) (His tag)

Catalog No. ABIN1098543

This Recombinant HAX1 protein is expressed in Escherichia coli (E. coli).

Quick Overview for HAX1 Protein (AA 1-279) (His tag) (ABIN1098543)

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 80% by SDS-PAGE

Product Details

Protein Characteristics: AA 1-279

Purification tag / Conjugate: This HAX1 protein is labelled with His tag.

Sequence: MGSSHHHHHH SSGLVPRGSH MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR

Purification: purified by chromatography

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1 M NaCl

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Alternative Name: HAX-1

Background: HAX1 is known to associate with HS1, a substrate of Src family tyrosine kinases. It also interacts with the product of PKD2, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with F-actin-binding protein, cortactin. It is associated with autosomal recessive severe congenital neutropenia, also known as Kostmann syndrome. Recombinant human HAX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Molecular Weight: 33.7 kDa (299aa) confirmed by MALDI-TOF

NCBI Accession: NP_006109

Pathways: Regulation of Actin Filament Polymerization