PDCD10 Protein (His tag)
Quick Overview for PDCD10 Protein (His tag) (ABIN1589742)
Target
See all PDCD10 ProteinsProtein Type
Origin
Source
Purity
-
-
Purification tag / Conjugate
- This PDCD10 protein is labelled with His tag.
-
Purpose
- CCM-3
-
Sequence
- MGSSHHHHHH SSGLVPRGSM RMTMEEMKNE AETTSMVSMP LYAVMYPVFN ELERVNLSAA QTLRAAFIKA EKENPGLTQD IIMKILEKKS VEVNFTESLL RMAADDVEEY MIERPEPEFQ DLNEKARALK QILSKIPDEI NDRVRFLQTI KDIASAIKEL LDTVNNVFKK YQYQNRRALE HQKKEFVKYS KSFSDTLKTY FKDGKAINVF VSANRLIHQT NLILQTFKTV A
-
Specificity
- Chromosomal location:3q26.1
-
Characteristics
- Length (aa):231
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!ProductExpression SystemConjugateOriginPrice starts atExpression System HEK-293 CellsConjugate His tagOrigin HumanPrice starts at $12,595.45Expression System Cell-free protein synthesis (CFPS)Conjugate Strep TagOrigin HumanPrice starts at $18,117.43Your project requires further customization? Contact us and discover our custom protein solutions
-
Programmed Cell Death 10 (PDCD10) (AA 1-212) protein (His tag)
custom-made PDCD10 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Programmed Cell Death 10 (PDCD10) (AA 1-212) protein (His tag)custom-made PDCD10 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Programmed Cell Death 10 (PDCD10) (AA 1-212) protein (GST tag)PDCD10 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Programmed Cell Death 10 (PDCD10) (AA 1-212), (full length) protein (His-SUMO Tag)PDCD10 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Programmed Cell Death 10 (PDCD10) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PDCD10 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
Comment
-
Cytokines & Growth Factors
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- The lyophilized CCM3 is soluble in water and most aqueous buffers and should be reconstituted in water or PBS.
-
Buffer
- PBS
-
Storage
- -20 °C,-80 °C
-
Storage Comment
- Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted CCM-3 should be stored in working aliquots at -20°C.
-
Expiry Date
- 6 months
-
-
- PDCD10 (Programmed Cell Death 10 (PDCD10))
-
Alternative Name
- CCM-3
-
Background
-
Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011). The CCM-3 is fused to a N-terminal His-tag (6x His).
Synonyms: PDCD10, CCM3, TFAR15, programmed cell death 10 -
Molecular Weight
- 26.7 kDa
-
Gene ID
- 11235
-
NCBI Accession
- NM_007217, NP_009148
-
UniProt
- Q9BUL8
Target
-
