LAMP1 Protein (AA 29-382) (Fc Tag)

Catalog No. ABIN1691541

Recombinant LAMP1 protein expressed in Human Cells.

Quick Overview for LAMP1 Protein (AA 29-382) (Fc Tag) (ABIN1691541)

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 29-382

Purification tag / Conjugate: This LAMP1 protein is labelled with Fc Tag.

Purpose: Recombinant Human LAMP1/CD107a (C-Fc)

Sequence: AMFMVKNGNG TACIMANFSA AFSVNYDTKS GPKNMTFDLP SDATVVLNRS SCGKENTSDP SLVIAFGRGH TLTLNFTRNA TRYSVQLMSF VYNLSDTHLF PNASSKEIKT VESITDIRAD IDKKYRCVSG TQVHMNNVTV TLHDATIQAY LSNSSFSRGE TRCEQDRPSP TTAPPAPPSP SPSPVPKSPS VDKYNVSGTN GTCLLASMGL QLNLTYERKD NTTVTRLLNI NPNKTSASGS CGAHLVTLEL HSEGTTVLLF QFGMNASSSR FFLQGIQLNT ILPDARDPAF KAANGSLRAL QATVGNSYKC NAEEHVRVTK AFSVNIFKVW VQAFKVEGGQ FGSVEECLLD ENSMVDDIEG RMDEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSREEMTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGK

Characteristics:

Recombinant Human LAMP1/CD107a (C-Fc)

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Alternative Name: Lysosome-Associated Membrane Glycoprotein 1/LAMP1

Background: Recombinant Human Lysosome-Associated Membrane Glycoprotein 1/LAMP1 is produced by our mammalian expression system. The target protein is expressed with sequence (Ala29-Met382) of Human LAMP1fused with a FC tag at the C-terminus.
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells(PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

Molecular Weight: 65.5 kDa

UniProt: P11279

Pathways: Autophagy