MMP12 Protein (AA 106-267, Catalytic Domain)

Catalog No. ABIN1883193

This Recombinant MMP12 protein is expressed in Escherichia coli (E. coli).

Quick Overview for MMP12 Protein (AA 106-267, Catalytic Domain) (ABIN1883193)

Target: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Product Details

Protein Characteristics: AA 106-267, Catalytic Domain

Characteristics: The sequence corresponding to the catalytic domain (aa 106-267) of Human MMP-12 was expressed in E. Coli.

Purification: Purified from bacterial lysate and refolded using proprietary technique.

Application Details

Restrictions: For Research Use only

Handling

Storage: -80 °C

Target Details

Target: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Alternative Name: MMP-12

Background: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is involved in smoke-induced emphysema, tumor and other diseases. MMP-12 is secreted as a 54 kDa zymogen and becomes the mature 54 kDa active form after proteolytic cleavage. MMP-12 has a broad range of substrates, including alpha-1 proteinase inhibitor, alpha-2 antiplasmin, plasminogen activator inhibitor-2, collagen IV, laminin, fibronectin, elastin, but not interstitial collagens.

Molecular Weight: 18 kDa

NCBI Accession: NP_002417