Complement Component 5a (C5a) (AA 679-751) (Active) Protein

Details for Product No. ABIN2180666, Supplier: Log in to see
Protein Name
  • C5a
  • C5b
  • CPAMD4
  • Hc
  • RGD1561905
  • complement C5
  • C5
Protein Characteristics
AA 679-751
Escherichia coli (E. coli)
Protein Type
Biological Activity
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Characteristics This protein carries no "tag". The protein has a calculated MW of 8.3 kDa. The protein migrates as 8.3 kDa under reducing (R) condition (SDS-PAGE).
Purity >95 % as determined by SDS-PAGE.
Sterility 0.22 μm filtered
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Biological Activity Comment Biological Activity: rhC5a is active based on enzyme release assay of myeloperoxidase. The ED50 = 1.36 nM.
Background Human Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells, C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation, C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism, C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system, C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
Molecular Weight 8.3 kDa
UniProt P01031
Pathways Complement System, Carbohydrate Homeostasis
Restrictions For Research Use only
Format Lyophilized
Reconstitution Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
Supplier Images
SDS-PAGE (SDS) image for Complement Component 5a (C5a) (AA 679-751) (Active) protein (ABIN2180666) Human C5a, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained ove...
Background publications Belo, Pinheiro, Reis, Ricklefs, Braga: "Prevalence and lineage diversity of avian haemosporidians from three distinct cerrado habitats in Brazil." in: PLoS ONE, Vol. 6, Issue 3, pp. e17654, 2011 (PubMed).

Monk, Scola, Madala, Fairlie: "Function, structure and therapeutic potential of complement C5a receptors." in: British journal of pharmacology, Vol. 152, Issue 4, pp. 429-48, 2007 (PubMed).

Gerard, Gerard: "Receptor-dependent internalization of platelet-activating factor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 152, Issue 2, pp. 793-800, 1994 (PubMed).

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