DPP4 Protein (AA 29-766) (Fc Tag)

Catalog No. ABIN2180984

This Recombinant DPP4 protein is produced in HEK-293 Cells. There is 1 publication available.

Quick Overview for DPP4 Protein (AA 29-766) (Fc Tag) (ABIN2180984)

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 29-766

Purification tag / Conjugate: This DPP4 protein is labelled with Fc Tag.

Sequence: AA 29-766

Characteristics: This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 112 kDa. The protein migrates as 90-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

References

Kleine-Weber, Elzayat, Wang, Graham, Müller, Drosten, Pöhlmann, Hoffmann: "Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization." in: Journal of virology, Vol. 93, Issue 2, (2019) (PubMed).

Target Details

Target: DPP4 (Dipeptidyl-Peptidase 4 (DPP4))

Alternative Name: DPPIV

Background: Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.[4] DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

Molecular Weight: 112.3 kDa

NCBI Accession: NP_001926

Pathways: Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity