BMP3 Protein
Quick Overview for BMP3 Protein (ABIN2468285)
Target
See all BMP3 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MQWIEPRNCA RRYLKVDFAD IGWSEWIISP KSFDAYYCSG ACQFPMPKSL KPSNHATIQS IVRAVGVVPG IPEPCCVPEK MSSLSILFFD ENKNVVLKVY PNMTVESCAC R
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Characteristics
- Biological activity was determined by its ability to inhibit BMP-2-induced alkaline phosphatase production by ATDC-5 cells.
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Endotoxin Level
- Endotoxin level is less than 0.1 ng per μg (1 EU/μg).
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Bone Morphogenetic Protein 3 (BMP3) (AA 373-472) protein (GST tag)
BMP3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 3 (BMP3) (AA 1-472) protein (GST tag)BMP3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Bone Morphogenetic Protein 3 (BMP3) (AA 363-472) protein (His tag)BMP3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Bone Morphogenetic Protein 3 (BMP3) protein (Myc-DYKDDDDK Tag)BMP3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Handling Advice
- As with any protein, exposing BMP-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -20 °C
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Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted BMP-3 stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Expiry Date
- 24 months
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- BMP3 (Bone Morphogenetic Protein 3 (BMP3))
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Alternative Name
- BMP-3
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Background
- TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-3 is abundantly found in adult bone, and to a lesser extent fetal cartilage. BMP-3 inhibits osteogenesis and bone formation by activating a signaling cascade that antagonizes the signaling of pro-osteogenic BMPs. Recombinant human BMP-3 is a disulfide linked homodimeric protein that corresponds to residues 361 to 472 of the 472 amino acid BMP-3 precursor protein.
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Gene ID
- 651
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NCBI Accession
- NP_001192
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OMIM
- 126507087
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UniProt
- P12645
Target
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