IL-24 Protein
Quick Overview for IL-24 Protein (ABIN2468661)
Target
See all IL-24 (IL24) ProteinsProtein Type
Origin
Source
Purity
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Sequence
- QEFHFGPCQV KGVVPQKLWE AFWAVKDTMQ AQDNITSARL LQQEVLQNVS DAESCYLVHT LLEFYLKTVF KNYHNRTVEV RTLKSFSTLA NNFVLIVSQL QPSQENEMFS IRDSAHRRFL LFRRAFKQLD VEAALTKALG EVDILLTWMQ KFYKLHHHHH H
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Interleukin 24 (IL24) (AA 51-206) (Active) protein (His tag)
IL24 Origin: Human Host: Escherichia coli (E. coli) > 90 % AcA, CC Active
Interleukin 24 (IL24) (AA 58-167) protein (GST tag)IL24 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 24 (IL24) (AA 1-206) protein (GST tag)IL24 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 24 (IL24) (AA 1-207) protein (GST tag)IL24 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Handling Advice
- As with any protein, exposing IL-24 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
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Storage
- -20 °C
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Storage Comment
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted IL-24 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
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Expiry Date
- 24 months
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- IL-24 (IL24) (Interleukin 24 (IL24))
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Alternative Name
- IL-24
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Background
- IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include the induction of differentiation and apoptosis, and the suppression of angiogenesis and cell proliferation. Recombinant human IL-24 is an 18.9 kDa glycoprotein, containing 161 amino acid residues, including a C-terminal His-tag.
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Gene ID
- 11009
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NCBI Accession
- NP_001172085
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OMIM
- 297632401
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UniProt
- Q13007
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Autophagy
Target
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