IRAK1 Protein (AA 618-712) (His tag)
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- Target See all IRAK1 Proteins
- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 618-712
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IRAK1 protein is labelled with His tag.
- Application
- Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)
- Purity
- ~95 %
- Top Product
- Discover our top product IRAK1 Protein
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Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 1-710) protein (His tag)
custom-made IRAK1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 504-712) protein (GST tag)IRAK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 1-633) protein (GST tag)IRAK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (AA 1-712) protein (His tag)custom-made IRAK1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)IRAK1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 100 mM sodium phosphate, 500 mM NaCl, 25 mM imidazole, 10 % gycerol
- Handling Advice
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Storage
- -80 °C
- Storage Comment
- Store in working aliquots at -70 °C.
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- Target
- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
- Alternative Name
- IRAK (IRAK1 Products)
- Background
- Nuclear factor kappa B (NF-?B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-?B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF? and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently (1,2). IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response (3). IRAK mediates a signaling cascade leading to NF-?B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF) (1,4).
- Molecular Weight
- 15 kDa (Calculated)
- Gene ID
- 3654
- OMIM
- 8928535
- UniProt
- P51617
- Pathways
- NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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