alpha-Thrombin Protein

Catalog No. ABIN2965565

Native alpha-Thrombin protein expressed in Pig.

Quick Overview for alpha-Thrombin Protein (ABIN2965565)

Target: alpha-Thrombin

Protein Type: Native

Origin: Pig

Source: Pig

Product Details

Characteristics: Porcine Thrombin

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized Powder from 20mM PBS, pH 7.4 containing 0.9% NaCl.It is recommended to reconstitute the lyophilized Thrombin in sterile 18M omega cm H 2 O.

Storage: -20 °C

Target Details

Target: alpha-Thrombin

Alternative Name: Thrombin

Background: Introduction: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.