Caspase 1 Protein (CASP1)
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- Target See all Caspase 1 (CASP1) Proteins
- Caspase 1 (CASP1)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Bacteria
- Characteristics
- ~8000 units/mg. One unit cleaves 1 nmol of the caspase substrate YVAD-pNA per hour at 37°C in a reaction solution containing 50 mM HEPES, pH 7.2, 50 mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10 mM DTT.
- Top Product
- Discover our top product CASP1 Protein
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Caspase 1 (CASP1) (AA 120-269) protein (His tag)
CASP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Caspase 1 (CASP1) (AA 120-404) protein (His tag)CASP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Caspase 1 (CASP1) (AA 1-100) protein (GST tag)CASP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Caspase 1 (CASP1) (AA 1-311) protein (GST tag)CASP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Caspase 1 (CASP1) (AA 315-402) protein (His tag)Crystallography grade CASP1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Caspase 1 (CASP1) (AA 120-297) protein (His tag)Crystallography grade CASP1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Caspase 1 (CASP1) (AA 120-269), (partial) protein (GST tag)CASP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % ELISA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with PBS to 1 unit/µl.
- Storage
- -80 °C
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- Target
- Caspase 1 (CASP1)
- Alternative Name
- Caspase-1 (CASP1 Products)
- Synonyms
- ICE Protein, IL1BC Protein, P45 Protein, Il1bc Protein, Ice Protein, CASP1 Protein, CG5370 Protein, DCP-1 Protein, DCP1 Protein, Dcp1 Protein, Dmel\\CG5370 Protein, ccp1 Protein, dcp-1 Protein, dcp1 Protein, l(2)01862 Protein, l(2)02132 Protein, caspase 1 Protein, caspase 1, apoptosis-related cysteine peptidase Protein, caspase 4, apoptosis-related cysteine peptidase Protein, Death caspase-1 Protein, caspase-1 Protein, caspase Protein, caspase recruitment domain-containing protein 16 Protein, caspase 4 Protein, CASP1 Protein, Casp1 Protein, CASP4 Protein, Dcp-1 Protein, Caspase1 Protein, LOC5564196 Protein, LOC451519 Protein
- Background
- Caspase-1 (also known as ICE, Interleulin-1- Converting Enzyme) is the prototypical member of the caspase family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa pro-enzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive pro-enzyme form.
- Molecular Weight
- 45 kDa
- Pathways
- Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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