Annexin V Protein (FITC,GST tag)
Quick Overview for Annexin V Protein (FITC,GST tag) (ABIN5564291)
Target
See all Annexin V (ANXA5) ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This Annexin V protein is labelled with FITC,GST tag.
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Purpose
- Annexin V (human) (rec.) (FITC)
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Specificity
- Binds to phosphatidylserine (PS).
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Cross-Reactivity
- Human
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Characteristics
- Recombinant human annexin V fused to a GST-tag.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In PBS, pH 7.4, containing 0.02 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handling Advice
- Do not freeze. Protect from light.
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Storage
- 4 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: +4°C
Use & Stability: Stable for at least 1 year after receipt when stored at +4°C.
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Expiry Date
- 12 months
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- Annexin V (ANXA5) (Annexin A5 (ANXA5))
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Alternative Name
- Annexin V
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Background
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Annexin A5, Endonexin II, Lipocortin V, Placental Anticoagulant Protein I, Calphobindin I, Vascular Anticoagulant-alpha
Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.
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Molecular Weight
- ~52kDa (SDS-PAGE)
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UniProt
- P08758
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Pathways
- Apoptosis
Target
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