LOXL2 Protein (AA 26-776) (His tag)
LOXL2
Origin: Mouse
Host: Yeast
Recombinant
> 90 %
SDS
1 image
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- Target See all LOXL2 Proteins
- LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-776
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Origin
- Mouse
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Source
- Yeast
- Purification tag / Conjugate
- This LOXL2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- QYEGWPYQLQ YPEYFQQPAP EHHQRQVPSD VVKIQVRLAG QKRKHNEGRV EVYYEGQWGT VCDDDFSIHA AHVVCRQVGY VEAKSWAASS SYGPGEGPIW LDNIYCTGKE STLASCSSNG WGVTDCKHTE DVGVVCSEKR IPGFKFDNSL INQIESLNIQ VEDIRIRPIL SAFRHRKPVT EGYVEVKEGK AWKQICNKHW TAKNSHVVCG MFGFPAEKTY NPKAYKTFAS RRKLRYWKFS MNCTGTEAHI SSCKLGPSVT RDPVKNATCE NGQPAVVSCV PSQIFSPDGP SRFRKAYKPE QPLVRLRGGA QVGEGRVEVL KNGEWGTICD DKWDLVSASV VCRELGFGTA KEAITGSRLG QGIGPIHLNE VQCTGTEKSI IDCKFNTESQ GCNHEEDAGV RCNIPIMGFQ KKVRLNGGRN PYEGRVEVLT ERNGSLVWGT VCGQNWGIVE AMVVCRQLGL GFASNAFQET WYWHGNIFAN NVVMSGVKCS GTELSLAHCR HDEEVACPEG GVRFGAGVAC SETAPDLVLN AEIVQQTAYL EDRPMSLLQC AMEENCLSAS AVHTDPTRGH RRLLRFSSQI HNNGQSDFRP KNGRHAWIWH DCHRHYHSME VFTYYDLLSL NGTKVAEGHK ASFCLEDTEC EGDIQKSYEC ANFGEQGITM GCWDMYRHDI DCQWIDITDV PPGDYLFQVV INPNYEVPES DFSNNIMKCR SRYDGYRIWM YNCHVGGAFS EETEQKFEHF SGLLNNQLSV Q
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product LOXL2 Protein
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Lysyl Oxidase-Like 2 (LOXL2) (AA 26-776) protein (His tag)
LOXL2 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- LOXL2 (Lysyl Oxidase-Like 2 (LOXL2))
- Alternative Name
- LOXL2 (LOXL2 Products)
- Background
- Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (T) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 . Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.1 Publication
- Molecular Weight
- 86.43 kDa
- UniProt
- P58022
- Pathways
- Chromatin Binding
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