SERPINC1 Protein (AA 33-464) (His tag)

Catalog No. ABIN5853560

Recombinant SERPINC1 protein expressed in Escherichia coli (E. coli).

Quick Overview for SERPINC1 Protein (AA 33-464) (His tag) (ABIN5853560)

Target: SERPINC1 (Serpin Family C Member 1 (SERPINC1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 85 % by SDS - PAGE

Product Details

Protein Characteristics: AA 33-464

Purification tag / Conjugate: This SERPINC1 protein is labelled with His tag.

Sequence: MGSSHHHHHH SSGLVPRGSH MGSHGSPVDI CTAKPRDIPM NPMCIYRSPE KKATEDEGSE QKIPEATNRR VWELSKANSR FATTFYQHLA DSKNDNDNIF LSPLSISTAF AMTKLGACND TLQQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SKLVSANRLF GDKSLTFNET YQDISELVYG AKLQPLDFKE NAEQSRAAIN KWVSNKTEGR ITDVIPSEAI NELTVLVLVN TIYFKGLWKS KFSPENTRKE LFYKADGESC SASMMYQEGK FRYRRVAEGT QVLELPFKGD DITMVLILPK PEKSLAKVEK ELTPEVLQEW LDELEEMMLV VHMPRFRIED GFSLKEQLQD MGLVDLFSPE KSKLPGIVAE GRDDLYVSDA FHKAFLEVNE EGSEAAASTA VVIAGRSLNP NRVTFKANRP FLVFIREVPL NTIIFMGRVA NPCVK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Denatured

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: SERPINC1 (Serpin Family C Member 1 (SERPINC1))

Alternative Name: SERPINC1

Background: Antithrombin-III precursor, also known as SERPINC1, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The inhibitory activity of SERPINC1 is amplified in the presence of heparin. SERPINC1 inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia. Recombinant human SERPINC1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molecular Weight: 51.4kDa (455aa)

NCBI Accession: NP_000479

UniProt: P01008