CNTF Receptor alpha Protein (AA 23-342) (His tag)
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- Target See all CNTF Receptor alpha (CNTFR) Proteins
- CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 23-342
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Origin
- Rat
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Source
- Baculovirus infected Insect Cells
- Purification tag / Conjugate
- This CNTF Receptor alpha protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- QKHSPQEAPH VQYERLGTDV TLPCGTASWD AAVTWRVNGT DLAPDLLNGS QLILRSLELG HSGLYACFHR DSWHLRHQVL LHVGLPPREP VLSCRSNTYP KGFYCSWHLS APTYIPNTFN VTVLHGSKMM VCEKDPALKN RCHIRYMHLF STIKYKVSIS VSNALGHNTT AITFDEFTIV KPDPPENVVA RPVPSNPRRL EVTWQTPSTW PDPESFPLKF FLRYRPLILD QWQHVELSNG TAHTITDAYA GKEYIIQVAA KDNEIGTWSD WSVAAHATPW TEEPRHLTTE AQAPETTTST TSSLAPPPTT KICDPGELSS LEHHHHHH
- Purity
- > 90 % by SDS - PAGE
- Endotoxin Level
- < 1.0 EU per 1 microgram of protein (determined by LAL method)
- Top Product
- Discover our top product CNTFR Protein
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Ciliary Neurotrophic Factor Receptor (CNTFR) (Active) protein (His tag)
CNTFR Origin: Rat Host: Baculovirus infected Insect Cells Recombinant > 97 % as determined by SDS-PAGE Active
Ciliary Neurotrophic Factor Receptor (CNTFR) (AA 23-346) protein (His tag)CNTFR Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Ciliary Neurotrophic Factor Receptor (CNTFR) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)CNTFR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In Phosphate Buffered Saline ( pH 7.4) containing 10 % glycerol.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))
- Alternative Name
- Cntfr (CNTFR Products)
- Background
- Cntfr, also known as ciliary neurotrophic factor receptor subunit alpha, is a member of the type 1 cytokine receptor family. It mediates the biological action of CNTF. CNTF is a polypeptide hormone that supports the survival of neurons of the peripheral sensory, sympathetic, and ciliary ganglia at various stages in their development. CNTFR and its cognate ligand support the survival of neurons. The CNTF receptor complex is most closely related to, and shares subunits with the receptor complexes for interleukin-6 and leukemia inhibitory factor. The specificity conferring alpha subunit of the CNTF complex (CNTFR alpha), is extremely well conserved across species, and has a distribution localized predominantly to the nervous system and skeletal muscle. Recombinant rat Cntfr, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
- Molecular Weight
- 36.9kDa (328aa) 40-57KDa (SDS-PAGE under reducing conditions.)
- NCBI Accession
- NP_001003929
- UniProt
- Q08406
- Pathways
- JAK-STAT Signaling, Feeding Behaviour
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