Interleukin 10 (IL10) (AA 1-178) protein (Fc Tag)

Details for Product No. ABIN6253271
Protein Name
  • CSIF
  • GVHDS
  • IL-10
  • IL10A
  • TGIF
  • Il-10
  • IL10X
  • interleukin 10
  • IL10
  • Il10
Protein Characteristics
AA 1-178
52
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Origin
Mouse (Murine)
72
31
20
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Source
CHO Cells
100
26
16
10
4
2
1
Protein Type
Recombinant
Purification tag / Conjugate
This IL-10 protein is labelled with Fc Tag.
Options
Purpose IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)
Specificity The extracellular domain of mouse IL-10 (aa 1-178) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
Characteristics Protein. The extracellular domain of mouse IL-10 (aa 1-178) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
Purity >98 % (SDS-PAGE)
Endotoxin Level <0.06EU/μg protein (LAL test, Lonza).
Biological Activity Comment Shows the biological function of the IL-10 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Protein Name
Background

Alternate Names/Synonyms: Interleukin-10, Cytokine Sythesis Inhibitory Factor, CSIF

Product Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location, Cancer Immune Checkpoints
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized from 0.2μm-filtered solution in PBS.
Handling Advice Avoid freeze/thaw cycles.
Storage 4 °C,-20 °C
Storage Comment

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Did you look for something else?