Interleukin 10 (IL10) (AA 19-178) (Active) Protein

Details for Product No. ABIN2018051, Supplier: Log in to see
Protein Name
  • CSIF
  • GVHDS
  • IL-10
  • IL10A
  • TGIF
  • Il-10
  • IL10X
  • interleukin 10
  • IL10
  • Il10
Protein Characteristics
AA 19-178
56
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Origin
Human
82
38
23
4
4
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Source
CHO Cells
118
26
20
8
3
2
1
Protein Type
Recombinant
Biological Activity
Active
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Characteristics ED50 < 0.2 ng/mL, measured in a cell proliferation assay using MC/9 cells.
Purity > 95 % as analyzed by SDS-PAGE and HPLC.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Protein Name
Background Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80 % sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory, however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported.
Synonyms: B-TCGF, CSIF, TGIF
Molecular Weight 18-19 kDa, observed by reducing SDS-PAGE.
UniProt P22301
Pathways Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/mL.
Buffer Lyophilized after extensive dialysis against PBS.
Storage -80 °C
Storage Comment Lyophilized recombinant Human Interleukin-10 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Interleukin-10 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
Expiry Date 6 months
Supplier Images
SDS-PAGE (SDS) image for Interleukin 10 (IL10) (AA 19-178) (Active) protein (ABIN2018051) 5 μg of IL-10, Human was resolved with SDS-PAGE under reducing (R) and non-reducing ...
 image for Interleukin 10 (IL10) (AA 19-178) (Active) protein (ABIN2018051) Interleukin 10 (IL10) (AA 19-178) (Active) protein (Image 2)
Activity Assay (AcA) image for Interleukin 10 (IL10) (AA 19-178) (Active) protein (ABIN2018051) IL-10, Human stimulates cell proliferation of the MC/9 cells. The ED50 for this effec...
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