CD38 Protein (AA 44-301) (His tag)
Quick Overview for CD38 Protein (AA 44-301) (His tag) (ABIN6253545)
Target
See all CD38 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 44-301
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Purification tag / Conjugate
- This CD38 protein is labelled with His tag.
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Sequence
- AA 44-301
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM MES, 100 mM NaCl, pH 6.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- CD38
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Background
- CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
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Molecular Weight
- 31.8 kDa
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NCBI Accession
- NP_001274206
Target
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