PGC Protein (AA 17-388) (His tag)

Catalog No. ABIN6387837

This Recombinant PGC protein is produced in Baculovirus infected Insect Cells.

Quick Overview for PGC Protein (AA 17-388) (His tag) (ABIN6387837)

Target: PGC (Pepsinogen C (PGC))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: SDS-PAGE (SDS)

Purity: > 95% by SDS-PAGE

Product Details

Protein Characteristics: AA 17-388

Purification tag / Conjugate: This PGC protein is labelled with His tag.

Sequence: AVVKVPLKKF KSIRETMKEK GLLGEFLRTH KYDPAWKYRF GDLSVTYEPM AYMDAAYFGE ISIGTPPQNF LVLFDTGSSN LWVPSVYCQS QACTSHSRFN PSESSTYSTN GQTFSLQYGS GSLTGFFGYD TLTVQSIQVP NQEFGLSENE PGTNFVYAQF DGIMGLAYPA LSVDEATTAM QGMVQEGALT SPVFSVYLSN QQGSSGGAVV FGGVDSSLYT GQIYWAPVTQ ELYWQIGIEE FLIGGQASGW CSEGCQAIVD TGTSLLTVPQ QYMSALLQAT GAQEDEYGQF LVNCNSIQNL PSLTFIINGV EFPLPPSSYI LSNNGYCTVG VEPTYLSSQN GQPLWILGDV FLRSYYSVYD LGNNRVGFAT AA

Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details

Target: PGC (Pepsinogen C (PGC))

Alternative Name: Pepsinogen C/PGC

Background: PGC, also known as gastricsin, is an aspartic proteinase that belongs to the peptidase family A1. It is synthesized in the gastric mucosa as inactive precursors. It contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. Serum levels of PGC are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Recombinant human PGC, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Molecular Weight: 41.6 kDa (380aa)

NCBI Accession: NP_002621

UniProt: P20142