UBE2N Protein (AA 1-152) (His tag)

Catalog No. ABIN666632

This Recombinant UBE2N protein is produced in Escherichia coli (E. coli).

Quick Overview for UBE2N Protein (AA 1-152) (His tag) (ABIN666632)

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 95 % by SDS - PAGE

Product Details

Protein Characteristics: AA 1-152

Purification tag / Conjugate: This UBE2N protein is labelled with His tag.

Characteristics: UBE2N, 1-152aa, Human, His tag, E.coli

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, Q10010.1M NaCl,1mM DTT

Storage: 4 °C

Target Details

Target: UBE2N (Ubiquitin-Conjugating Enzyme E2N (UBE2N))

Alternative Name: UBE2N

Background: UBE2N, also known as UBC13, is a member of the E2 ubiquitin-conjugating enzyme family. It catalyzes the ATP-dependent synthesis of non-canonical polyubiquitin chains, a process that does not lead to proteasomal degradation. It mediates the transcription of several target genes and is thought to play a role in cell cycle progression, cellular differentiation and DNA repair mechanisms that ensure cell survival after DNA damage. Recombinant human UBE2N protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Ubiquitin-conjugating enzyme E2 N, MGC131857, MGC8489, UBC13, UbcH-ben. NCBI no.: NP_003339

Molecular Weight: 19.3 kDa(172aa), confirmed by MALDI-TOF

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Positive Regulation of Response to DNA Damage Stimulus, Ubiquitin Proteasome Pathway