SPR Protein (AA 1-261) (His tag)
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- Target See all SPR Proteins
- SPR (Sepiapterin Reductase (SPR))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-261
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SPR protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- Sepiapterin reductase, 1-261 aa, Human, His-tagged, Recombinant, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product SPR Protein
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Sepiapterin Reductase (SPR) (AA 1-261) protein (His tag)
custom-made SPR Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Sepiapterin Reductase (SPR) (AA 1-261) protein (His tag)custom-made SPR Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Sepiapterin Reductase (SPR) (AA 1-261) protein (GST tag)SPR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Sepiapterin Reductase (SPR) (AA 1-262) protein (His tag)SPR Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
Sepiapterin Reductase (SPR) protein (Myc-DYKDDDDK Tag)SPR Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20 mM Tris-HCl buffer (pH 8.0)
- Storage
- 4 °C
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- Target
- SPR (Sepiapterin Reductase (SPR))
- Alternative Name
- Sepiapterin reductase (SPR Products)
- Background
- Sepiapterin reductase (SPR) belongs to the short-chain dehydrogenase/reductase (SDR) family and also reduces various exogenous carbonyl compounds including phenylpropanedione. SPR is an essential enzyme for the biosynthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. Defects in SPR cause DOPA-responsive dystonia defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Recombinant human SPR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: SPR, Sepiapterin reductase. NCBI no.: NP_003115
- Molecular Weight
- 30.2 kDa (281aa), confirmed by MALDI-TOF.
- Pathways
- Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration
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