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Retinoid X Receptor alpha Protein (AA 111-228)

This Recombinant Retinoid X Receptor alpha protein is expressed in Escherichia coli (E. coli).
Catalog No. ABIN666801

Quick Overview for Retinoid X Receptor alpha Protein (AA 111-228) (ABIN666801)

Target

See all Retinoid X Receptor alpha (RXRA) Proteins
Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

Protein Type

Recombinant

Origin

  • 9
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  • 1
  • 1
Human

Source

  • 4
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  • 2
Escherichia coli (E. coli)

Application

SDS-PAGE (SDS)

Purity

> 95 %
  • Protein Characteristics

    AA 111-228

    Sequence

    MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE

    Characteristics

    RXR-alpha( Retinoid x receptor, 111-228aa, Human) Recombinant, expressed in E.coli)

    Purification

    > 95% by SDS-PAGE
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  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    20 mM Tris-HCl buffer ( pH 7.5) containing 0.1M NaCl, 5 mM beta-Mercaptoethanol

    Storage

    4 °C,-20 °C,-80 °C

    Storage Comment

    Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
  • Target

    Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))

    Alternative Name

    RXR alpha/RXRA

    Background

    The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR). The RXR family includes three difference isoforms , RXR alpha, beta, gamma. Human RXR alpha gene is localized on 9q34. 9 and encodes two major isoforms (RXR alpha1, RXR alpha2). The DNA binding domain of RXR (111-228aa) was over expressed in E. coli and purified by using conventional column chromatography techniques.

    Molecular Weight

    13.5 kDa (119aa) confirmed by MALDI-TOF

    NCBI Accession

    NP_002948

    Pathways

    Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Hepatitis C
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