Retinoid X Receptor alpha Protein (AA 111-228)
Quick Overview for Retinoid X Receptor alpha Protein (AA 111-228) (ABIN666801)
Target
See all Retinoid X Receptor alpha (RXRA) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 111-228
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Sequence
- MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
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Characteristics
- RXR-alpha( Retinoid x receptor, 111-228aa, Human) Recombinant, expressed in E.coli)
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Purification
- > 95% by SDS-PAGE
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 20 mM Tris-HCl buffer ( pH 7.5) containing 0.1M NaCl, 5 mM beta-Mercaptoethanol
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- Retinoid X Receptor alpha (RXRA) (Retinoid X Receptor, alpha (RXRA))
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Alternative Name
- RXR alpha/RXRA
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Background
- The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR). The RXR family includes three difference isoforms , RXR alpha, beta, gamma. Human RXR alpha gene is localized on 9q34. 9 and encodes two major isoforms (RXR alpha1, RXR alpha2). The DNA binding domain of RXR (111-228aa) was over expressed in E. coli and purified by using conventional column chromatography techniques.
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Molecular Weight
- 13.5 kDa (119aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_002948
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Pathways
- Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Hepatitis C
Target
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