RGS17 Protein (AA 1-210) (His tag)

Catalog No. ABIN667548

This Recombinant RGS17 protein is expressed in Escherichia coli (E. coli).

Quick Overview for RGS17 Protein (AA 1-210) (His tag) (ABIN667548)

Target: RGS17 (Regulator of G-Protein Signaling 17 (RGS17))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 90 % by SDS - PAGE

Product Details

Protein Characteristics: AA 1-210

Purification tag / Conjugate: This RGS17 protein is labelled with His tag.

Characteristics: RGS17, 1-210aa, Human, His tag, E.coli

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl,1mM DTT

Storage: 4 °C

Target Details

Target: RGS17 (Regulator of G-Protein Signaling 17 (RGS17))

Alternative Name: RGS17

Background: RGS17, also known as regulator of G-protein signaling 17, attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. It plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs. Recombinant human RGS17 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Regulator of G-protein signaling 17, hRGS17, RGS-17, RGSZ2. NCBI no.: NP_036551

Molecular Weight: 26.5 kDa(230aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling