RCAN1 Protein (AA 1-117)

Catalog No. ABIN667702

Recombinant RCAN1 protein expressed in Escherichia coli (E. coli).

Quick Overview for RCAN1 Protein (AA 1-117) (ABIN667702)

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Protein Characteristics: AA 1-117

Sequence: MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS

Characteristics: DSCR1 isoform b, 1-117aa , Human, Recombinant, E.coli

Purification: > 90% by SDS-PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 20 mM Tris-HCl buffer ( pH 7.5) containing 0.1M NaCl, 1 mM DTT, 10 % Glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Alternative Name: Calcipressin-1/DSCR1

Background: The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.

Molecular Weight: 13.2 kDa (117aa) confirmed by MALDI-TOF

NCBI Accession: NP_981962

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development