tau-441 (AA 1-441) protein (His tag)

Catalog No. ABIN6809918

This Recombinant protein is produced in Escherichia coli (E. coli).

Quick Overview for tau-441 (AA 1-441) protein (His tag) (ABIN6809918)

Target: tau-441

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: >90 % as determined by reduced SDS-PAGE.

Product Details

Protein Characteristics: AA 1-441

Purification tag / Conjugate: His tag

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH 7.5

Storage: -20 °C

Target Details

Target: tau-441

Background: Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

Molecular Weight: 47.9 kDa

NCBI Accession: NP_005901