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IL-33 Protein (AA 109-270) (His tag)

This Recombinant IL-33 protein is produced in HEK-293 Cells. There is 1 publication available.
Catalog No. ABIN6938888

Quick Overview for IL-33 Protein (AA 109-270) (His tag) (ABIN6938888)

Target

See all IL-33 (IL33) Proteins
IL-33 (IL33) (Interleukin 33 (IL33))

Protein Type

Recombinant

Biological Activity

Active

Origin

  • 21
  • 20
  • 4
  • 2
  • 1
  • 1
  • 1
Human

Source

  • 29
  • 11
  • 2
  • 2
  • 1
  • 1
HEK-293 Cells

Purity

>95 % as determined by SDS-PAGE.
  • Protein Characteristics

    AA 109-270

    Purification tag / Conjugate

    This IL-33 protein is labelled with His tag.

    Sequence

    AA 109-270

    Endotoxin Level

    Less than 1.0 EU per μg by the LAL method.
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    Product
    Expression System
    Conjugate
    Origin
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    Expression System HEK-293 Cells
    Conjugate His tag
    Origin Human
    Price starts at $12,595.45
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    Origin Human
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Buffer

    PBS, pH 7.4

    Handling Advice

    Please avoid repeated freeze-thaw cycles.

    Storage

    -20 °C
  • Wu, Li, Xia, Tian, Kong, Wang, Gu, Zhang, Tu, Xie, Yang, Lu, Jiang, Ying: "Identification of Human Single-Domain Antibodies against SARS-CoV-2." in: Cell host & microbe, (2020) (PubMed).

  • Target

    IL-33 (IL33) (Interleukin 33 (IL33))

    Alternative Name

    IL-33

    Background

    Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

    Molecular Weight

    20.2 kDa

    Pathways

    Production of Molecular Mediator of Immune Response
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