IL-33 Protein (AA 109-270) (His tag)
Quick Overview for IL-33 Protein (AA 109-270) (His tag) (ABIN6938888)
Target
See all IL-33 (IL33) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 109-270
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Purification tag / Conjugate
- This IL-33 protein is labelled with His tag.
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Sequence
- AA 109-270
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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: "Identification of Human Single-Domain Antibodies against SARS-CoV-2." in: Cell host & microbe, (2020) (PubMed).
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: "Identification of Human Single-Domain Antibodies against SARS-CoV-2." in: Cell host & microbe, (2020) (PubMed).
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- IL-33 (IL33) (Interleukin 33 (IL33))
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Alternative Name
- IL-33
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Background
- Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
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Molecular Weight
- 20.2 kDa
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Pathways
- Production of Molecular Mediator of Immune Response
Target
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