GPC2 Protein (AA 24-553) (Fc Tag)
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- Target See all GPC2 Proteins
- GPC2 (Glypican 2 (GPC2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-553
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GPC2 protein is labelled with Fc Tag.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GPC2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
- Storage
- -20 °C
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- Target
- GPC2 (Glypican 2 (GPC2))
- Alternative Name
- Glypican 2 (GPC2 Products)
- Synonyms
- 2410016G05Rik Protein, glypican 2 Protein, glypican 2 (cerebroglycan) Protein, GPC2 Protein, Gpc2 Protein
- Background
- Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
- Molecular Weight
- 37.3 kDa & 47.3 kDa
- NCBI Accession
- NP_689955
- Pathways
- Glycosaminoglycan Metabolic Process
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