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Glypican 2 (GPC2) (AA 24-553) protein (Fc Tag) Protein

GPC2 Origin: Human Source: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Catalog No. ABIN6952250
$2,541.00
Plus shipping costs $45.00
1 mg
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  • Protein Name
    Protein Type
    Recombinant
    Protein Characteristics
    AA 24-553
    Origin
    Human
    Source
    HEK-293 Cells
    Purification tag / Conjugate
    Fc Tag
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Storage
    -20 °C
  • Protein Name
    Background
    Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
    Molecular Weight
    37.3 kDa & 47.3 kDa
    NCBI Accession
    NP_689955
    Pathways
    Glycosaminoglycan Metabolic Process
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