Melanoma gp100 Protein (AA 25-595) (Fc Tag)
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- Target See all Melanoma gp100 (PMEL) Proteins
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 25-595
- Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Melanoma gp100 protein is labelled with Fc Tag.
- Purpose
- Recombinant human PMEL Protein with C-terminal Human Fc tag
- Specificity
- PMEL (Lys25-Ala595) hFc (Glu99-Ala330)
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product PMEL Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
- Alternative Name
- PMEL (PMEL Products)
- Background
- This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
- Molecular Weight
- predicted molecular mass of 46.2 kDa after removal of the signal peptide.The apparent molecular mass of PMEL-hFc is 130-250 kDa due to glycosylation.
- Gene ID
- 6490
- UniProt
- P40967
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