Calreticulin Protein (CALR) (AA 18-417) (His tag)
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- Target See all Calreticulin (CALR) Proteins
- Calreticulin (CALR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 18-417
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Calreticulin protein is labelled with His tag.
- Purpose
- Recombinant human CALR protein with C-terminal 6xHis tag
- Specificity
- CALR (Glu18-Leu417) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CALR Protein
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Calreticulin (CALR) protein (His tag)
CALR Origin: Human Host: Escherichia coli (E. coli) Recombinant >90 % (SDS-PAGE) SDS
Calreticulin (CALR) (AA 25-199) protein (His-IF2DI Tag)CALR Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Calreticulin (CALR) (AA 1-417) protein (GST tag)CALR Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calreticulin (CALR) (AA 18-417) protein (His tag)CALR Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- Calreticulin (CALR)
- Alternative Name
- CALR (CALR Products)
- Background
- Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
- Molecular Weight
- predicted molecular mass of 47.3 kDa after removal of the signal peptide.The apparent molecular mass of CALR-His is 55-70 kDa due to glycosylation.
- UniProt
- P27797
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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