TGFBR2 Protein (AA 23-159) (His tag)
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- Target See all TGFBR2 Proteins
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 23-159
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TGFBR2 protein is labelled with His tag.
- Sequence
- AA 23-159
- Characteristics
- Biotinylated Mouse TGF-beta RII / TGFBR2 Protein, His,Avitag™
- Purity
- >90 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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- Discover our top product TGFBR2 Protein
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- Application Notes
- MALS verified
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))
- Alternative Name
- TGF-beta RII (TGFBR2 Products)
- Background
- TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
- Molecular Weight
- 17.4 kDa
- NCBI Accession
- NP_003233
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