GFRAL Protein (AA 19-351) (His tag)

Catalog No. ABIN7092777

Product Details

Target: GFRAL (GDNF Family Receptor alpha Like (GFRAL))

Protein Type: Recombinant

Protein Characteristics: AA 19-351

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This GFRAL protein is labelled with His tag.

Purpose: Recombinant human GFRAL protein with C-terminal 6xHis tag

Specificity: GFRAL (Ser19-Glu351) 6xHis tag

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: GFRAL (GDNF Family Receptor alpha Like (GFRAL))

Alternative Name: GFRAL (GFRAL Products)

Background: Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]

Molecular Weight: predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of GFRAL-His is 35-55 kDa due to glycosylation.

UniProt: Q6UXV0