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BMPR1A Protein (His tag,Fc Tag)

This Recombinant BMPR1A protein is produced in Human Cells.
Catalog No. ABIN7320751

Quick Overview for BMPR1A Protein (His tag,Fc Tag) (ABIN7320751)

Target

See all BMPR1A Proteins
BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Protein Type

Recombinant

Origin

  • 20
  • 4
  • 2
  • 1
  • 1
Mouse

Source

  • 9
  • 8
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human Cells

Purity

> 95 % as determined by SDS-PAGE
  • Purification tag / Conjugate

    This BMPR1A protein is labelled with His tag,Fc Tag.

    Purpose

    Recombinant Mouse BMPRIA/ALK-3 Protein (Fc & His Tag)

    Sequence

    Gln24-Arg152

    Characteristics

    Recombinant Mouse Bone Morphogenetic Protein Receptor Type IA/Activin Receptor-like Kinase 3 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg152 is expressed with a Fc, 6His tag at the C-terminus.

    Endotoxin Level

    < 1.0 EU per μg as determined by the LAL method.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

    Storage

    4 °C,-20 °C,-80 °C

    Storage Comment

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

    Alternative Name

    BMPRIA/ALK-3

    Background

    Background: ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A and BMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GS domain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS).

    Synonym: ALK-3,Bone morphogenetic protein receptor type-1A,BMP type-1A receptor,BMPR-1A,Activin receptor-like kinase 3,BMP-2/BMP-4 receptor,Serine/threonine-protein kinase receptor R5,SKR5,CD292,Acvrlk3,Bmpr,BMPR-IA

    Molecular Weight

    42.2 kDa

    UniProt

    P36895

    Pathways

    Stem Cell Maintenance
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