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C1D Protein (GST tag)

This Recombinant C1D protein is expressed in Escherichia coli (E. coli).
Catalog No. ABIN7317380

Quick Overview for C1D Protein (GST tag) (ABIN7317380)

Target

See all C1D Proteins
C1D (C1D Nuclear Receptor Corepressor (C1D))

Protein Type

Recombinant

Origin

  • 8
  • 2
  • 1
  • 1
  • 1
Human

Source

  • 4
  • 3
  • 3
  • 2
  • 1
Escherichia coli (E. coli)

Purity

> 80 % as determined by reducing SDS-PAGE.
  • Purification tag / Conjugate

    This C1D protein is labelled with GST tag.

    Purpose

    Recombinant Human C1D Protein (GST Tag)

    Sequence

    Met 1-Ser 141

    Characteristics

    A DNA sequence encoding the human C1D (Q13901) (Met 1-Ser 141) was fused with the GST tag at the N-terminus.
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from sterile PBS, pH 7.5

    Storage

    4 °C,-20 °C,-80 °C

    Storage Comment

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    C1D (C1D Nuclear Receptor Corepressor (C1D))

    Alternative Name

    C1D

    Background

    Background: C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid hormone receptor. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA, this function may include MPHOSPH6. It potentiates transcriptional repression by NR1D1 and THRB. C1D nuclear receptor corepressorcan activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. It also can induce apoptosis in a p53/TP53 dependent manner.

    Synonym: hC1D,LRP1,Rrp47,SUN-CoR,SUNCOR

    Molecular Weight

    43.2 kDa

    UniProt

    Q13901
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