S100A8/A9 Complex (Calprotectin) Protein (His tag)

Catalog No. ABIN7319332

This Recombinant S100A8/A9 Complex (Calprotectin) protein is expressed in Escherichia coli (E. coli).

Quick Overview for S100A8/A9 Complex (Calprotectin) Protein (His tag) (ABIN7319332)

Target: S100A8/A9 Complex (Calprotectin) (S100A8/A9) (Calprotectin (S100A8/A9))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This S100A8/A9 Complex (Calprotectin) protein is labelled with His tag.

Purpose: Recombinant Human S100A8&S100A9 Heterodimer Protein (His Tag)

Sequence: Met 1-Glu93(S100A8)&Thr 2-Pro114(S100A9)

Characteristics: Recombinant Human S100 Calcium Binding Protein S100A8/S100A9 Heterodimer is produced by our E.coli expression system and the target gene encoding Met1-Glu93(S100A8)&Thr2-Pro114(S100A9) is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HEPES,10 % Glycerol,150 mM NaCl,2.5 mM EDTA, pH 7.4.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: S100A8/A9 Complex (Calprotectin) (S100A8/A9) (Calprotectin (S100A8/A9))

Alternative Name: S100A8&S100A9 Heterodimer

Background:

Background: S100A8 is a member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. Calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.

Synonym: S100A8/S100A9 Heterodimer

Molecular Weight: 11.7&13.2 kDa

Pathways: S100 Proteins