CSNK1A1 Protein (GST tag)
Quick Overview for CSNK1A1 Protein (GST tag) (ABIN7317097)
Target
See all CSNK1A1 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Purification tag / Conjugate
- This CSNK1A1 protein is labelled with GST tag.
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Purpose
- Recombinant Human CSNK1A1/CKI-alpha/CK1 Protein (GST Tag)(Active)
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Sequence
- Met 1-Phe 337
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Characteristics
- A DNA sequence encoding the full length of human CSNK1A1 isoform 1 (P48729-1) (Met 1-Phe 337) was expressed with the GST tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 30 nmol/min/mg using casein as substrate.
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Casein Kinase 1, alpha 1 (CSNK1A1) (AA 1-337) protein (GST tag)
CSNK1A1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Casein Kinase 1, alpha 1 (CSNK1A1) (AA 1-337) protein (His tag)CSNK1A1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % by SDS - PAGE SDS
Casein Kinase 1, alpha 1 (CSNK1A1) (AA 2-337) protein (His tag)CSNK1A1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Casein Kinase 1, alpha 1 (CSNK1A1) proteinCSNK1A1 Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, ELISA, IP
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 2 mM GSH, pH 7.4
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))
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Alternative Name
- CSNK1A1/CKI-alpha/CK1
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Background
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Background: Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.
Synonym: CK1;CK1a;CKIa;HEL-S-77p;HLCDGP1;PRO2975
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Molecular Weight
- 65.2 kDa
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Pathways
- WNT Signaling, Hedgehog Signaling
Target
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