CD1b Protein (CD1B) (Fc Tag)
Quick Overview for CD1b Protein (CD1B) (Fc Tag) (ABIN7317475)
Target
See all CD1b (CD1B) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This CD1b protein is labelled with Fc Tag.
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Purpose
- Recombinant Human CD1B/CD1A Protein (Fc Tag)
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Sequence
- Met 1-Ser 303
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Characteristics
- A DNA sequence encoding the human CD1B (NP_001755) (Met1-Ser 303) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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CD1b (CD1B) (AA 18-303) protein (His tag)
CD1B Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
CD1b (CD1B) (AA 1-333) protein (GST tag)CD1B Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
CD1b (CD1B) protein (Myc-DYKDDDDK Tag)CD1B Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile PBS, pH 7.4
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CD1b (CD1B)
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Alternative Name
- CD1B/CD1A
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Background
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Background: CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. During protein synthesis and maturation, they bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. CD1B localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.. It is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1B is an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Synonym: CD1,CD1A,CD1B,R1
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Molecular Weight
- 58.6 kDa
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NCBI Accession
- NP_001755
Target
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