C1QBP Protein (His tag)

Catalog No. ABIN7320370

Recombinant C1QBP protein expressed in Escherichia coli (E. coli).

Quick Overview for C1QBP Protein (His tag) (ABIN7320370)

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 92 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This C1QBP protein is labelled with His tag.

Purpose: Recombinant Mouse C1QBP Protein (His Tag)

Sequence: Leu 72-Gln 279

Characteristics: A DNA sequence encoding the mature form of mouse C1QBP (NP_031599.2) (Leu 72-Gln 279) was expressed, with a polyhistide tag at the N-terminus.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))

Alternative Name: C1QBP

Background:

Background: Hyaluronan binding protein 1 (HABP1), also known as p32 or gC1qR, is a ubiquitously expressed multifunctional phospho-protein implicated in cell signalling. Hyaluronan-binding protein 1 (HABP1) /p32/gC1qR was characterized as a highly acidic and oligomeric protein, which binds to different ligands like hyaluronan, C1q, and mannosylated albumin. The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro. HABP1 overexpressing cells showed extensive vacuolation and reduced growth rate, which was corrected by frequent medium replenishment. Further investigation revealed that HABP1 overexpressing cells undergo apoptosis, and they failed to enter into the S-phase. The sperm surface HABP1 level can be correlated with the degree of sperm motility.Hyaluronan binding protein 1 (HABP1) was reported to be present on human sperm surface and its involvement in fertilization has already been elucidated: decreased HABP1 level may be associated with low motility of sperms, which in turn might cause infertility in the patient. HABP1 also is an endogenous substrate for MAP kinase and upon mitogenic stimulation it is translocated to the nucleus in a MAP kinase-dependent manner.

Synonym: AA407365,AA986492,D11Wsu182e,gC1qBP,HABP1,P32

Molecular Weight: 24.7 kDa

NCBI Accession: NP_031599

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly