DCLK1 Protein (AA 1-705) (GST tag,His tag)
Quick Overview for DCLK1 Protein (AA 1-705) (GST tag,His tag) (ABIN7317068)
Target
See all DCLK1 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 1-705
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Purification tag / Conjugate
- This DCLK1 protein is labelled with GST tag,His tag.
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Purpose
- Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)(Active)
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Sequence
- Met 1-Val 705
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Characteristics
- A DNA sequence encoding the human DCLK1 (O15075-1) (Met 1-Val 705) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 6.1 nmol/min/mg using synthetic Autocamtide-2 peptide (KKALRRQETVDAL-amide) as substrate.
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Doublecortin-Like Kinase 1 (DCLK1) (AA 1-756) protein (His tag)
custom-made DCLK1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Doublecortin-Like Kinase 1 (DCLK1) (AA 1-740) protein (His tag)custom-made DCLK1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Doublecortin-Like Kinase 1 (DCLK1) (AA 586-740) protein (His-IF2DI Tag)DCLK1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
Doublecortin-Like Kinase 1 (DCLK1) (AA 640-729) protein (GST tag)DCLK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 0.5 mM PMSF
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))
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Alternative Name
- DCAMKL1
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Background
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Background: DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.
Synonym: CL1,CLICK1,DCAMKL1,DCDC3A,DCLK
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Molecular Weight
- 106 kDa
Target
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