FRZB Protein (His tag)

Catalog No. ABIN7317893

This Recombinant FRZB protein is expressed in HEK-293 Cells.

Quick Overview for FRZB Protein (His tag) (ABIN7317893)

Target: FRZB (Frizzled-Related Protein (FRZB))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: > 85 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This FRZB protein is labelled with His tag.

Purpose: Recombinant Human FRZB/sFRP-3 Protein (His Tag)

Sequence: Ala32-Asn325

Characteristics: A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: FRZB (Frizzled-Related Protein (FRZB))

Alternative Name: FRZB/sFRP-3

Background:

Background: FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.

Synonym: FRE,FRITZ,FRP-3,FRZB-1,FRZB-PEN,FRZB1,FZRB,hFIZ,OS1,SFRP3,SRFP3

Molecular Weight: 34.5 kDa

NCBI Accession: NP_001454

Pathways: WNT Signaling, Positive Regulation of fat Cell Differentiation