IL-33 Protein (His tag)
Quick Overview for IL-33 Protein (His tag) (ABIN7318673)
Target
See all IL-33 (IL33) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This IL-33 protein is labelled with His tag.
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Purpose
- Recombinant Human Interleukin-33/IL-33 Protein (His Tag)
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Sequence
- Ser112-Thr 270
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Characteristics
- Recombinant Human Interleukin-33 is produced by our E.coli expression system and the target gene encoding Ser112-Thr270 is expressed with a 6His tag at the N-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, 1 mM EDTA, pH 8.0.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- IL-33 (IL33) (Interleukin 33 (IL33))
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Alternative Name
- Interleukin-33/IL-33
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Background
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Background: Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines from polarized Th2 cells.
Synonym: Interleukin-33, IL-33, Interleukin-1 Family Member 11, IL-1F11, Nuclear Factor From High Endothelial Venules, NF-HEV, IL33, C9orf26, IL1F11, NFHEV
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Molecular Weight
- 20.3 kDa
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UniProt
- O95760
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Pathways
- Production of Molecular Mediator of Immune Response
Target
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