Kallikrein 2 Protein (KLK2) (His tag)

Catalog No. ABIN7318697

This Recombinant Kallikrein 2 protein is produced in Human Cells.

Quick Overview for Kallikrein 2 Protein (KLK2) (His tag) (ABIN7318697)

Target: Kallikrein 2 (KLK2)

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Kallikrein 2 protein is labelled with His tag.

Purpose: Recombinant Human Kallikrein 2/KLK2 Protein (His Tag)

Sequence: Pro19-Pro261

Characteristics: Recombinant Human Kallikrein 2 is produced by our Mammalian expression system and the target gene encoding Pro19-Pro261 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Citrate, 150 mM NaCl, pH 3.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Kallikrein 2 (KLK2)

Alternative Name: Kallikrein 2/KLK2

Background:

Background: Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.

Synonym: Kallikrein-2, Glandular Kallikrein-1, hGK-1, Tissue Kallikrein-2, KLK2

Molecular Weight: 27.9 kDa

UniProt: P20151

Pathways: Complement System