Lactate Dehydrogenase A Protein (LDHA) (His tag)

Catalog No. ABIN7320609

Recombinant Lactate Dehydrogenase A protein expressed in Human Cells.

Quick Overview for Lactate Dehydrogenase A Protein (LDHA) (His tag) (ABIN7320609)

Target: Lactate Dehydrogenase A (LDHA)

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purity: > 95 % as determined by SDS-PAGE

Product Details

Purification tag / Conjugate: This Lactate Dehydrogenase A protein is labelled with His tag.

Purpose: Recombinant Mouse LDHA/LDH1 Protein (His Tag)

Sequence: Met1-Phe332

Characteristics: Recombinant Mouse L-lactate dehydrogenase is produced by our Mammalian expression system and the target gene encoding Met1-Phe332 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Lactate Dehydrogenase A (LDHA)

Alternative Name: LDHA/LDH1

Background:

Background: Mouse Lactate dehydrogenase A (LDHA) is a member of the LDH/MDH superfamily and LDH family. LDHA catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria.

Synonym: LDHA,Ldh1,L-lactate dehydrogenase

Molecular Weight: 37.5 kDa

UniProt: P06151

Pathways: Warburg Effect