Latexin Protein (LXN) (His tag)
Quick Overview for Latexin Protein (LXN) (His tag) (ABIN7196736)
Target
See all Latexin (LXN) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This Latexin protein is labelled with His tag.
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Purpose
- Recombinant Human Latexin/LXN Protein (His Tag)
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Sequence
- Glu 2-Glu222
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Characteristics
- A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu222) was expressed, fused with a polyhistidine tag at the N-terminus.
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Latexin (LXN) (AA 1-222) protein (His tag)
custom-made LXN Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Latexin (LXN) (AA 1-222) protein (His tag)custom-made LXN Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Latexin (LXN) (AA 2-222) protein (His-IF2DI Tag)LXN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Latexin (LXN) (AA 1-222) protein (GST tag)LXN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Latexin (LXN) (Active) protein (His tag)LXN Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE Active
Latexin (LXN) (AA 1-222) proteinLXN Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % pure SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 20 mM HEPES, 0.1M KCl, pH 7.5
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Latexin (LXN)
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Alternative Name
- Latexin/LXN
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Background
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Background: Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.
Synonym: ECI;TCI
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Molecular Weight
- 26.8 kDa
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NCBI Accession
- NP_064554
Target
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