Lipocalin 2 Protein (LCN2) (His tag)
Quick Overview for Lipocalin 2 Protein (LCN2) (His tag) (ABIN7318826)
Target
See all Lipocalin 2 (LCN2) ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This Lipocalin 2 protein is labelled with His tag.
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Purpose
- Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, Human Cells)
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Sequence
- Gln21-Gly198
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Characteristics
- Recombinant Human Neutrophil gelatinase-associated lipocalin is produced by our Mammalian expression system and the target gene encoding Gln21-Gly198 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Lipocalin 2 (LCN2) (AA 21-198) protein (Fc Tag)
LCN2 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) (AA 21-198) protein (His tag)LCN2 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lipocalin 2 (LCN2) protein (His tag)LCN2 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Lipocalin 2 (LCN2) protein (Fc Tag)LCN2 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Lipocalin 2 (LCN2) (AA 1-198) protein (GST tag)LCN2 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 Origin: Rat Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
Lipocalin 2 (LCN2) (Active) protein (His tag)LCN2 Origin: Mouse Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of PBS, 50 % glycerol, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Lipocalin 2 (LCN2)
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Alternative Name
- NGAL/Lipocalin-2
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Background
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Background: LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Synonym: Neutrophil gelatinase-associated lipocalin, NGAL, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25, HNL, NGAL
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Molecular Weight
- 21.6 kDa
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UniProt
- P80188
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
Target
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